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KMID : 1038820150180010017
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Pediatric Gastroenterology, Hepatology & Nutrition
2015 Volume.18 No. 1 p.17 ~ p.22
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The Efficacy of Saccharomyces boulardii CNCM I-745 in Addition to Standard Helicobacter pylori Eradication Treatment in Children
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Zhang Bin
Xu Ya-Zheng
Deng Zhao-Hui
Chu Bo
Jiang Li-Rong
Yvan Vandenplas
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Abstract
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Purpose: This study aims to investigate Saccharomyces boulardii CNCM I-745 during Helicobacter pylori eradicationin children.
Methods: One hundred ninety-four H. pylori positive children were randomized in two groups. Therapy (omeprazole+clarithromycin+amoxicillin or omeprazole+clarithromycin+metronidazole in case of penicillin allergy) was givento both groups during two weeks. In the treatment group (n: 102) S. boulardii was added to the triple therapy, whilethe control group (n: 92) only received triple therapy. The incidence, onset, duration and severity of diarrhea and complianceto the eradication treatment were compared. A 13C urea breath test was done 4 weeks after the end of eradicationtherapy in two groups of 21 patients aged 12 years and older to test the H. pylori eradication rate.
Results: In the treatment group, diarrhea occurred in 12 cases (11.76%), starting after 6.25±1.24 days, lasting3.17±1.08 days, and compliance to eradication treatment was 100%. In the control group, diarrhea occurred in 26cases (28.26%), starting after 4.05±1.11 days, lasting 4.02±0.87 days, and in six cases eradication treatment wasstopped prematurely (p＜0.05). The 13C urea breath test showed successful H. pylori eradication in 71.4% of thepatients in the treatment and in 61.9 % in the control group (not significant).
Conclusion: S. boulardii has a beneficial effect on the prevention and treatment of diarrhea during H. pylori eradicationin children. Although S. boulardii did only slightly increase H. pylori eradication rate, compliance to eradication treatmentwas improved.
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KEYWORD
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Child, Compliance, Helicobacter pylori, Diarrhea, Prevention & control, Probiotics, Yeasts
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